5-Bromo-7-azaindole CAS 183208-35-7 use for Pharmaceutical Discovery and Synthetic Organic Chemistry CAS NO.183208-35-7

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Description of 5-Bromo-7-azaindole from Wuhan Fortuna Chemical Co.,Ltd

Application of 5-Bromo-7-azaindole CAS 183208-35-7 use for Pharmaceutical Discovery and Synthetic Organic Chemistry

5-Bromo-7-azaindole is a brominated heterocyclic compound, structurally similar to indole, with a nitrogen atom replacing one of the carbons in the ring. It has several applications, particularly in organic chemistry, drug discovery, and materials science:

### 1. **Pharmaceutical and Drug Discovery**:

   - **Lead Compound for Drug Development**: It is used as a building block or intermediate in the synthesis of biologically active compounds, particularly in medicinal chemistry. Its structure resembles the core of many bioactive molecules, making it a useful starting point for drug design, especially in the areas of kinase inhibitors and other enzyme-targeting drugs.

   - **Fragment-based Drug Discovery (FBDD)**: 5-Bromo-7-azaindole is often used in FBDD, where small molecular fragments are screened for binding to biological targets. The indole-like structure allows for interaction with a variety of protein active sites, while the bromine atom can serve as a point for further functionalization.

### 2. **Synthetic Organic Chemistry**:

   - **Cross-Coupling Reactions**: The bromine atom in 5-Bromo-7-azaindole makes it a useful substrate for cross-coupling reactions (e.g., Suzuki, Stille, or Sonogashira couplings). This allows for the formation of complex molecules by linking different organic fragments.

   - **Heterocyclic Synthesis**: Its azaindole structure is a useful motif in the synthesis of more complex heterocyclic systems. Such heterocycles are common in biologically active molecules.

### 3. **Materials Science**:

   - **Organic Electronics**: Derivatives of 5-Bromo-7-azaindole may be used in the design and synthesis of organic semiconductors and other materials for electronic applications, such as organic light-emitting diodes (OLEDs) and organic photovoltaics.

### 4. **Chemical Biology**:

   - **Probe Development**: It can be modified to develop chemical probes to study biological processes. The indole core can interact with various biomolecules, and the bromine allows for easy modification to tune its biological activity.

In summary, 5-Bromo-7-azaindole is valuable for developing new pharmaceuticals, materials, and tools for chemical biology due to its versatile reactivity and bioactivity potential.

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