DisodiuM trans-crocetinate CAS NO.591230-99-8

Description of Disodium trans-crocetinate from Wuhan Fortuna Chemical Co.,Ltd

What is Disodium trans-crocetinate

Disodium trans-crocetinate (DTC) is an experimental drug that aims to improve oxygen delivery to tissues by increasing oxygen diffusion through the blood plasma. It works by altering the structure of water molecules in blood plasma, which enhances the capacity for oxygen to move from blood to tissues without relying on red blood cells or hemoglobin. DTC has been explored for use in medical conditions where tissues suffer from inadequate oxygen supply (hypoxia), such as cancer, stroke, and traumatic brain injury. By enhancing oxygen diffusion, DTC could potentially improve the effectiveness of radiation therapy in cancer treatment or help protect the brain and other tissues from damage due to low oxygen levels. It remains in experimental stages, and its safety, efficacy, and potential therapeutic uses are still under clinical investigation.

Application of Disodium trans-crocetinate

Disodium trans-crocetinate (DTC) has been studied for several potential medical applications, primarily in conditions where tissue oxygenation is compromised. Some of its key applications include:

1. Cancer Therapy (Radiation Enhancement)DTC has been explored for use in cancer treatment, particularly in combination with radiation therapy. Tumors often have areas of hypoxia (low oxygen levels), which make them resistant to radiation, as oxygen enhances the damaging effects of radiation on cancer cells. By improving oxygen diffusion into tumor tissues, DTC could make tumors more vulnerable to radiation therapy, potentially increasing its effectiveness.

2. Stroke Treatment During ischemic stroke (caused by a blockage in blood flow to the brain), tissues suffer from hypoxia, leading to cell death. DTC’s ability to enhance oxygen delivery to oxygen-starved brain tissues may help limit the extent of brain damage and improve recovery after a stroke. This makes it a potential neuroprotective agent.

3. Traumatic Brain Injury (TBI) Traumatic brain injuries often lead to reduced oxygen supply in brain tissues. DTC could improve oxygenation in damaged brain areas, reducing the risk of further injury due to hypoxia and promoting healing.

4. Severe Hypoxia and Respiratory Conditions DTC has been investigated for treating severe hypoxia resulting from conditions like acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). By improving oxygen delivery to tissues even when the lungs are not functioning optimally, DTC may help support patients with critical respiratory failure.

5. Cardiovascular Conditions In certain heart conditions, such as ischemic heart disease or heart failure, tissues may not receive sufficient oxygen due to reduced blood flow. DTC’s ability to increase oxygen diffusion could potentially be applied in these scenarios to reduce tissue damage and improve outcomes.

6. Wound Healing Impaired oxygenation in tissues can delay wound healing. DTC might be applied to improve oxygen diffusion to injured or ischemic areas, potentially aiding the healing process in chronic wounds or after surgery.

7. Organ Transplantation There is potential interest in using DTC to improve oxygenation in transplanted organs. By ensuring better oxygen delivery to the transplanted tissue during the critical phase after surgery, it may enhance organ survival and function. While these applications are promising, DTC is still largely in the experimental and clinical trial phases. Its effectiveness, safety, and real-world application are still being researched across these areas.

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