China manufacturer Supply Cocarboxylase CAS 154-87-0 with good price CAS NO.154-87-0

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Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.

We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

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Cocarboxylase is the coenzyme form of thiamine (vitamin B1), known chemically as thiamine pyrophosphate (TPP). It plays a critical role in cellular metabolism, particularly in enzymatic reactions involving the decarboxylation of alpha-keto acids, such as pyruvate and alpha-ketoglutarate, in key metabolic pathways like the Krebs cycle. Here's a detailed breakdown:

Key Points:

1. Structure: TPP consists of thiamine (vitamin B1) with two phosphate groups added, making it the active coenzyme form.

2. Function:

   Decarboxylation Reactions: Facilitates the removal of carboxyl groups (-COOH) from molecules, such as converting pyruvate to acetyl-CoA (critical for entry into the Krebs cycle) and alpha-ketoglutarate to succinyl-CoA.                                                    Aldehyde Transfer: Acts as a cofactor in transketolase reactions in the pentose phosphate pathway, aiding in sugar metabolism.

3. Metabolic Importance:

   Essential for energy production (ATP synthesis) via carbohydrate metabolism.                                                                                      Supports nervous system function, as neurons rely heavily on glucose metabolism.

4. Deficiency Implications:

   Thiamine deficiency leads to impaired TPP production, causing disorders like beriberi (characterized by nerve, heart, and muscle issues) and Wernicke-Korsakoff syndrome (associated with alcoholism).

5. Medical Use:

   Administered clinically to treat thiamine deficiency or conditions like metabolic disorders, alcoholism, or malnutrition.

Historical Context:

The term "cocarboxylase" originates from its role as a coenzyme for carboxylase enzymes, though it is primarily involved in decarboxylation (removing CO?) rather than carboxylation (adding CO?). This naming reflects early biochemical nomenclature.

In summary, cocarboxylase (TPP) is vital for converting food into usable energy and maintaining neurological health, underscoring the importance of adequate thiamine intake through diet or supplements.