USP standard Proethylene glycol (PEG-400) CAS 25322-68-3 supplied by factory CAS NO.25322-68-3

Wuhan Fortuna Chemical Co.,Ltd is a professional integrative chemical enterprise with 18 years exporting experience,which is being engaged in Pharmaceutical and its intermediates, Food and Feed additives, Fine chemicals.

Polyethylene Glycol (PEG) is a synthetic, water-soluble polymer composed of repeating ethylene oxide units (?(CH?CH?O)??). Key aspects include:

Properties

Versatile Solubility: Miscible with water and organic solvents.

Non-Toxic & Biocompatible: Widely used in medical and consumer products.

Molecular Weight Variability: Ranges from liquids (low MW, e.g., PEG 400) to solids (high MW, e.g., PEG 20,000).

Applications

1. Pharmaceuticals:

   • Laxatives: PEG 3350 for bowel preparation.

   • Drug Delivery: Enhances solubility/stability of medications; key in mRNA vaccines (e.g., COVID-19 lipid nanoparticles).

   • Excipient: Binder in tablets and ointments.

2. Cosmetics: Moisturizer in creams/lotions.

3. Industry: Lubricant, antifoaming agent, or binder in manufacturing.

4. Biotech: PEGylation modifies proteins/nanoparticles to prolong circulation.

Safety

Generally recognized as safe (FDA-approved), but rare allergic reactions or impurities (e.g., ethylene oxide residuals) may occur.

Biodegradable under specific conditions.

Summary: PEG’s adaptability makes it indispensable in medicine, cosmetics, and industry, balancing efficacy with low toxicity.