China Suppliers Isorhamnetin CAS 480-19-3 with best quality CAS NO.480-19-3

Professional supplier Isorhamnetin CAS 480-19-3 with superior quality

Company profile

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.

We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

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Isorhamnetin is a naturally occurring O-methylated flavonol, a subclass of flavonoids, known for its diverse biological activities. Here's a structured overview:

1. Chemical Structure & Classification

Structure: A methylated derivative of quercetin, with a methoxy (-OCH?) group at the 3'-position of the B-ring.
Molecular formula: C??H??O?.

Classification: Flavonoid (flavonol subgroup).

2. Natural Sources

• Plants: Found in various medicinal herbs and foods:

  • Ginkgo biloba (leaves),

  • Hippophae rhamnoides (sea buckthorn),

  • Opuntia ficus-indica (prickly pear),

  • Apples, onions, and berries.

• Forms: Often exists as glycosides (e.g., isorhamnetin-3-O-glucoside) in plants.

3. Pharmacological Activities

Antioxidant: Scavenges free radicals and enhances cellular antioxidant defenses.

Anti-inflammatory: Inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and enzymes (e.g., COX-2).

Anticancer: Induces apoptosis and inhibits proliferation in cancer cells (e.g., breast, colon).

Cardioprotective: Reduces oxidative stress and improves endothelial function.

Antidiabetic: Enhances insulin sensitivity and inhibits α-glucosidase.

Neuroprotective: Potential role in mitigating Alzheimer’s and Parkinson’s pathologies.

4. Mechanisms of Action

Modulates signaling pathways: NF-κB, MAPK, PI3K/Akt.

Activates Nrf2, boosting antioxidant enzyme production (e.g., SOD, catalase).

Inhibits cyclooxygenase and lipoxygenase enzymes.

5. Applications

Nutraceuticals: Incorporated into supplements for antioxidant support.

Cosmeceuticals: Used in anti-aging skincare products for UV protection and collagen synthesis.

Drug Development: Investigated for cancer, diabetes, and neurodegenerative disease therapies.

6. Metabolism & Bioavailability

Absorption: Limited oral bioavailability due to low solubility and rapid metabolism.

Metabolism: Undergoes phase II metabolism (glucuronidation, sulfation) in the liver.

Excretion: Primarily via urine and feces.

7. Safety

Generally recognized as safe at dietary levels.

High doses may cause mild gastrointestinal issues; no significant toxicity reported in studies.

8. Recent Research Highlights

Antiviral Potential: Studied against SARS-CoV-2 via inhibition of viral proteases.

Gut Microbiota Interaction: Converted by gut bacteria into bioactive metabolites.

Isorhamnetin’s multifunctional properties make it a promising candidate for therapeutic and preventive health applications, though further clinical trials are needed to validate efficacy in humans. Always consult healthcare professionals before using it therapeutically.