Reliable manufacturer supply Etonogestrel Cas 54048-10-1 with high quality and good service CAS NO.54048-10-1

Professional supplier Etonogestrel Cas 54048-10-1 with superior quality

Company profile

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.

We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

our competitive advantage

Guaranteed purity

High quality & competitive price

Quality control

Fast feedback

Prompt shipment

Etonogestrel is the English/international nonproprietary name (INN) for a synthetic progestin (a form of progesterone) widely used in hormonal contraceptives. Below is a detailed breakdown:

1. Basic Information

Chemical Class: Third-generation progestogen (structurally related to desogestrel).

• Brand Names:

  • Nexplanon/Implanon: Subdermal contraceptive implant (etonogestrel + ethylene vinyl acetate).

  • NuvaRing: Vaginal ring (combined with ethinyl estradiol).

2. Pharmacology

• Mechanism of Action:

  • Binds to progesterone receptors, suppressing ovulation by inhibiting luteinizing hormone (LH).

  • Thickens cervical mucus (blocking sperm entry) and thins the endometrial lining (preventing implantation).

• Half-life: ~25–30 hours.

• Metabolism: Primarily hepatic (CYP3A4 enzymes).

3. Clinical Uses

• Contraception:

  • Implant: Single rod inserted under the skin of the upper arm, effective for 3 years.

  • Vaginal Ring: Worn for 3 weeks/month, releases hormones continuously.

• Other Applications:

  • Hormone replacement therapy (HRT) in specific cases.

  • Management of endometriosis or menstrual disorders.

4. Key Features

5. Chemical Structure

Derived from 19-nortestosterone, modified to enhance progestogenic activity and reduce androgenic effects.

Molecular formula: C??H??O?.

6. Safety Notes

Pregnancy: Avoid use (not teratogenic but contraindicated during pregnancy).

Drug Interactions: Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine) may reduce efficacy.

Summary

Etonogestrel is a potent synthetic progestin central to long-acting reversible contraceptives (LARCs). Its primary role is to prevent pregnancy via multiple mechanisms, offering a convenient and highly effective option for birth control. Always consult healthcare providers for personalized advice.