Manufacturer supply BP/USP Cefadroxil Cas66592-87-8 with best quality and price CAS NO.66592-87-8

Wuhan Fortuna Chemical Co.,Ltd is a professional integrative chemical enterprise with 18 years exporting experience,which is being engaged in Pharmaceutical and its intermediates, Food and Feed additives, Fine chemicals.

Cefadroxil is a first-generation cephalosporin antibiotic used to treat various bacterial infections. Here's a structured overview:

Key Features

Class: β-lactam antibiotic, part of the cephalosporin family.

Generation: First-generation, emphasizing activity against Gram-positive bacteria (e.g., Staphylococcus aureus, Streptococcus pyogenes), with limited Gram-negative coverage.

Mechanism: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Indications

Skin/Soft Tissue Infections: Cellulitis, impetigo.

Urinary Tract Infections (UTIs): Uncomplicated cystitis.

Respiratory Infections: Streptococcal pharyngitis ("strep throat").

Other: Mild to moderate infections caused by susceptible organisms.

Pharmacokinetics

Administration: Oral (capsules, tablets, or suspension).

Half-Life: ~1.5–2 hours, but longer duration of action compared to similar drugs (e.g., cephalexin), allowing once- or twice-daily dosing.

Excretion: Primarily renal; dosage adjustment needed in renal impairment.

Spectrum of Activity

Gram-Positive: Effective against methicillin-susceptible Staphylococcus aureus (MSSA), streptococci.

Gram-Negative: Limited coverage (e.g., E. coli, Klebsiella).

Side Effects

Common: Gastrointestinal upset (nausea, diarrhea), rash.

Rare: Allergic reactions (cross-reactivity possible in penicillin-allergic patients), C. difficile infection.

Contraindications & Precautions

Avoid: Hypersensitivity to cephalosporins or severe penicillin allergy.

Use with Caution: Renal dysfunction, pregnancy/lactation (generally safe but consult guidelines).

Brand Names

Duricef, Ultracef, and generic formulations.

Advantages

Convenient dosing due to prolonged activity.

Broad Gram-positive coverage for outpatient infections.

Resistance

Susceptible to β-lactamase degradation; less effective against β-lactamase-producing or methicillin-resistant Staphylococcus (MRSA).

Clinical Notes

Preferred for infections requiring less frequent dosing.

Monitor renal function in patients with kidney disease.

Summary: Cefadroxil is a versatile oral antibiotic for common bacterial infections, valued for its Gram-positive efficacy and dosing convenience. Always consider allergy history and renal function when prescribing.