Factory supply high quality D-Cycloserine Cas 68-41-7 with favorable price and good service CAS NO.68-41-7

Wuhan Fortuna Chemical Co.,Ltd is a professional integrative chemical enterprise with 18 years exporting experience,which is being engaged in Pharmaceutical and its intermediates, Food and Feed additives, Fine chemicals.

D-Cycloserine is a broad-spectrum antibiotic and NMDA receptor partial agonist with the following key aspects:

1. Chemical Structure & Mechanism

Structure: A cyclic derivative of the amino acid serine (C?H?N?O?), specifically the D-isomer (active form).

Antibiotic Action: Inhibits bacterial cell wall synthesis by blocking enzymes involved in peptidoglycan production (e.g., alanine racemase, D-alanine ligase).

Neurological Effect: Acts as a partial agonist at the glycine-binding site of NMDA receptors, modulating glutamate signaling to enhance synaptic plasticity and memory formation.

2. Medical Uses

Tuberculosis: Second-line treatment for drug-resistant TB (adjunct to primary therapies).

Psychiatric Disorders: Investigated for augmenting exposure therapy in PTSD, phobias, and OCD by facilitating fear extinction.

Neurodegenerative Research: Studied in Alzheimer’s disease for cognitive enhancement.

3. Pharmacokinetics

Administration: Oral or intravenous.

Metabolism: Minimal hepatic processing; primarily excreted unchanged in urine.

4. Side Effects & Risks

CNS Effects: Dizziness, headache, seizures (rare).

Psychiatric: Anxiety, agitation (especially at high doses).

Contraindications: Avoid in epilepsy, severe renal impairment, or alcohol use (interaction risk).

5. Research & Limitations

Dose-Dependent Effects: Low doses enhance NMDA activity; high doses may block it.

Mixed Clinical Results: Efficacy varies in mental health trials, requiring precise timing with psychotherapy.

6. Regulatory Status

FDA-Approved: For TB and urinary tract infections (limited use due to resistance).

Off-Label: Experimental in psychiatry under strict protocols.

Summary: D-Cycloserine bridges microbiology and neuroscience, offering dual antibiotic and neuroplasticity-enhancing properties. While niche in clinical use, it remains a tool for studying memory and treating resistant infections.