High quality Metoclopramide hydrochloride Cas 7232-21-5 with good price and fast delivery CAS NO.7232-21-5

Product Name:    METOCLOPRAMIDE HCL
Synonyms:    AKOS 92099;2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide;AHR-3070-C;Metoclopramide hydrochloride;LABOTEST-BB LT00772087;4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-benzamidmonohydroch;4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamidehydrochloride;CloproMate
CAS:    7232-21-5
MF:    C14H23Cl2N3O2
MW:    336.26
EINECS:    206-662-9
Product Categories:    Amines;Aromatics;Antagonists;Dopaminergics;Intermediates & Fine Chemicals;Pharmaceuticals;Neurotransmitters;Dopamine receptor
Mol File:    7232-21-5.mol

Description    Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.
Chemical Properties    White Solid
Originator    Primperan,Delagrange,France,1964
Uses    Antiemetic;5-HT3 antagonist
Uses    A D2DR inhibitor and an HTR3E inhibitor
Uses    Dopamine D2 receptor antagonist. Antiemetic.

Manufacturing Process

    The N-(diethylaminoethyl)-2-methoxy-4-aminobenzamide used as the starting material may be prepared from o-toluidine. The o-toluidine is initially nitrated with nitric acid to produce 4-nitro-o-toluidine. The 4-nitro-o-toluidine is then converted to 2-hydroxy-4-nitrotoluene by heating with nitrous acid. By reacting the resulting 2-hydroxy-4-nitrotoluene with dimethyl sulfate, 2- methoxy-4-nitrotoluene is formed. The 2-methoxy-4-nitrotoluene is oxidized with potassium permanganate to produce 2-methoxy-4-nitrobenzoic acid. The latter substituted benzoic acid is treated with thionyl chloride to form 2- methoxy-4-nitrobenzoyl chloride. A methyl ethyl ketone solution of the 2- methoxy-4-nitrobenzoyl chloride is added over a period of about 1 hours to a methyl ethyl ketone solution containing an equal molecular quantity of N,Ndiethylethylene diamine while stirring and maintaining the temperature between 0°C and 5°C. The N-(diethylaminoethyl)-2-methoxy-4- nitrobenzamide hydrochloride formed precipitates. It is filtered, washed twice with methyl ethyl ketone, dissolved in alcohol, and reduced catalytically in an absolute isopropyl alcohol solution to form N-(diethylaminoethyl)-2-methoxy- 4-aminobenzamide. The base is obtained by precipitating with sodium hydroxide.

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High quality Metoclopramide hydrochloride Cas 7232-21-5 with good price and fast delivery

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5. What’s your MOQ
Different products have different MOQ, such as:
1).Peptide products, the MOQ is 1 gram level.
2).Liquid products, the MOQ is usually 50-100ML.
3).API, the MOQ is 1KG.
4).Intermediate products and conventional product, the MOQ is 1KG; custom-tailored products, the MOQ depends on the production process.
5).Food additives and vitamin, the MOQ is usually one package: such as Vitamin C is 25KG/drum, Vitamin E oil or Vitamin A oil is 5KG/bag; Vitamin E powder or Vitamin A powder is 20KG/cartons.
6).Agrochemical, the MOQ is 1KG, except preparations.
6. How Should Package
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Company Information

Company profile
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. 
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.
We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

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