China Manufacturer Hot Selling Bleomycin sulfate CAS 9041-93-4 CAS NO.9041-93-4

Professional supplier Bleomycin sulfate CAS 9041-93-4 with superior quality

Company profile

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.

We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

our competitive advantage

Guaranteed purity

High quality & competitive price

Quality control

Fast feedback

Prompt shipment

Bleomycin Sulfate is a chemotherapeutic agent and antibiotic derived from the bacterium Streptomyces verticillus. It is primarily used in cancer treatment due to its ability to inhibit cancer cell growth. Here's a detailed overview:

Mechanism of Action

DNA Damage: Bleomycin induces single- and double-strand DNA breaks by forming complexes with metal ions (e.g., iron) and generating free radicals. This disrupts DNA synthesis and repair, particularly affecting cells in the G2 and M phases of the cell cycle.

Medical Uses

• Indications:

  • Testicular cancer (often combined with cisplatin and etoposide in the BEP regimen).

  • Hodgkin’s and non-Hodgkin’s lymphomas.

  • Squamous cell carcinomas (e.g., head, neck, cervical cancers).

  • Pleurodesis (to manage recurrent pleural effusions).

• Administration: Typically given intravenously, intramuscularly, or subcutaneously. Dosing is carefully monitored to avoid toxicity.

Side Effects

Pulmonary Toxicity: The most serious adverse effect is dose-dependent lung injury (interstitial pneumonitis progressing to pulmonary fibrosis). Risk factors include cumulative dose >400 units, age >70, and pre-existing lung disease.

Other Reactions: Skin hyperpigmentation, mucositis, fever, alopecia (less common than with other chemotherapies), and rare hypersensitivity reactions.

Pharmacology

Form: The sulfate salt enhances solubility and stability for injection.

Metabolism: Degraded by the enzyme bleomycin hydrolase, which is low in skin and lungs, explaining site-specific toxicity.

Monitoring & Precautions

Pulmonary Function Tests (PFTs): Required before and during treatment.

Dose Limitation: Cumulative lifetime dose capped (e.g., 400 units) to reduce lung toxicity risk.

Contraindications: Severe pre-existing pulmonary disease or hypersensitivity.

History

Discovery: Isolated in the 1960s from Streptomyces verticillus.

Brand Name: Marketed as Blenoxane®.

Key Considerations

Combination Therapy: Rarely used alone; typically part of multi-drug regimens.

Toxicity Management: Regular monitoring and dose adjustments are critical to mitigate lung damage.

Bleomycin sulfate remains a cornerstone in treating specific cancers despite its toxicity profile, emphasizing the need for careful patient selection and monitoring.