China Supplier high quality Ornidazole CAS 16773-42-5 with good service CAS NO.16773-42-5

Professional supplier Ornidazole CAS 16773-42-5 with superior quality

 

Company profile

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients’ requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.

We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

 

our competitive advantage

Guaranteed purity

High quality & competitive price

Quality control

Fast feedback

Prompt shipment

Ornidazole is a synthetic antimicrobial agent belonging to the nitroimidazole class, similar to metronidazole and tinidazole. It is primarily used to treat infections caused by anaerobic bacteria and protozoa. Below is a detailed overview:

Mechanism of Action:

Prodrug Activation: In anaerobic organisms, the nitro group of ornidazole is reduced, generating toxic metabolites that disrupt microbial DNA, leading to cell death.

Selective Toxicity: Effective against organisms with low redox potentials (e.g., anaerobes), sparing human cells.

Indications:

1. Protozoal Infections:

   • Amebiasis (intestinal and hepatic).

   • Giardiasis.

   • Trichomoniasis (genital infections).

2. Anaerobic Bacterial Infections:

   • Bacterial vaginosis.

   • Pelvic inflammatory disease.

   • Dental/oral infections.

   • Surgical prophylaxis (preventing post-operative anaerobic infections).

3. Off-label Uses: Helicobacter pylori eradication (in combination therapy).

Pharmacokinetics:

Half-life: ~12–14 hours (longer than metronidazole), allowing once/twice-daily dosing.

Metabolism: Hepatic, via CYP450 enzymes.

Excretion: Primarily renal (60–70%) and fecal.

Dosage Forms:

Oral tablets, intravenous infusion, and topical formulations (varies by country).

Dosing:

• Adults: Typical regimens include:

  • Trichomoniasis: 1.5 g single dose or 500 mg twice daily for 5 days.

  • Amebiasis: 1–2 g/day for 3–5 days.

• Pediatrics: Weight-based dosing (e.g., 25–40 mg/kg/day).

Side Effects:

Common: Nausea, headache, dizziness, dry mouth, metallic taste.                                                                                                                                Rare but Serious:

Peripheral neuropathy (with prolonged use).                                                                                                                                                                Seizures, encephalopathy.                                                                                                                                                                                              Allergic reactions (rash, Stevens-Johnson syndrome).                                                                                                                                          Disulfiram-like reaction (avoid alcohol during treatment).

Contraindications:

Hypersensitivity to nitroimidazoles.

First trimester of pregnancy (caution advised; Category B/C depending on region).

Severe hepatic impairment.

Drug Interactions:

Alcohol: Causes disulfiram-like reaction (flushing, vomiting).

Warfarin: Potentiates anticoagulant effect (monitor INR).

CYP450 Inducers/Inhibitors: May alter ornidazole levels.

Advantages Over Metronidazole:

Longer half-life for less frequent dosing.

Potentially better tolerability (reduced GI side effects).

Brand Names:

Tiberal, Ornida, Ladoran, and others (varies globally).

Resistance:

Cross-resistance with other nitroimidazoles (e.g., metronidazole) is possible.

Special Populations:

Pregnancy: Use cautiously; avoid in first trimester unless benefits outweigh risks.

Lactation: Excreted in breast milk; consult healthcare provider.

Hepatic/Renal Impairment: Dose adjustment may be needed.

Storage:

Room temperature, protected from light/moisture.

Ornidazole is a valuable alternative in settings where compliance or metronidazole resistance/tolerability is a concern. Always consult local guidelines for specific recommendations.